Melatonin: circadian rhythm regulator, chronobiotic, antioxidant and beyond.
نویسندگان
چکیده
For many years, melatonin has been known to interact with circadian rhythms. New evidence indicates that melatonin acts as a free radical scavenger and antioxidant. Moreover, melatonin prevents apoptosis in different types of cells, because it induces mRNA levels of several antioxidant enzymes. It is evident that melatonin is involved in the cellular bioenergetic system as a mechanism that counteracts the progression of Alzheimer's disease.
منابع مشابه
Circadian rhythms, melatonin and depression.
The master biological clock situated in the suprachiasmatic nuclei of the anterior hypothalamus plays a vital role in orchestrating the circadian rhythms of multiple biological processes. Increasing evidence points to a role of the biological clock in the development of depression. In seasonal depression and in bipolar disorders it seems likely that the circadian system plays a vital role in th...
متن کاملMood Disorders, Circadian Rhythms, Melatonin and Melatonin Agonists
Recent advances in the understanding of circadian rhythms have led to an interest in the treatment of major depressive disorder with chronobiotic agents. Many tissues have autonomous circadian rhythms, which are orchestrated by the master clock, situated in the suprachiasmatic nucleus (SNC). Melatonin (N-acetyl-5-hydroxytryptamine) is secreted from the pineal gland during darkness. Melatonin ac...
متن کاملRole of melatonin in the regulation of human circadian rhythms and sleep.
The circadian rhythm of pineal melatonin is the best marker of internal time under low ambient light levels. The endogenous melatonin rhythm exhibits a close association with the endogenous circadian component of the sleep propensity rhythm. This has led to the idea that melatonin is an internal sleep "facilitator" in humans, and therefore useful in the treatment of insomnia and the readjustmen...
متن کاملThe Melatonergic System in Mood and Anxiety Disorders and the Role of Agomelatine: Implications for Clinical Practice
Melatonin exerts its actions through membrane MT1/MT2 melatonin receptors, which belong to the super family of G-protein-coupled receptors consisting of the typical seven transmembrane domains. MT1 and MT2 receptors are expressed in various tissues of the body either as single ones or together. A growing literature suggests that the melatonergic system may be involved in the pathophysiology of ...
متن کاملCircadian rhythm disorders among adolescents: assessment and treatment options.
Delayed sleep phase disorder (DSPD) - a circadian rhythm sleep disorder - is most commonly seen in adolescents. The differential diagnosis between DSPD and conventional psychophysiological insomnia is important for correct therapeutic intervention. Adolescent DSPD sleep duration is commonly 9 hours or more. Depression may be comorbid with DSPD. DSPD has a negative impact on adolescent academic ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Clinics in dermatology
دوره 27 2 شماره
صفحات -
تاریخ انتشار 2009